Week 6 of the NFL season presents a handful of intriguing options as it pertains to player injuries.

Let's dive into the biggest injuries this week, and determine who may step up for their respective teams.

All stats are sourced from PFF and Sports Info Solutions.

New England Patriots RB Damien Harris

Game status: "Questionable"

Injury: Hamstring

As of today, Harris is being listed as "questionable", though he is likely to miss multiple games, per NFL Network's Tom Pelissero. We'll consider Harris far closer to doubtful than he is questionable for Week 6.

It shouldn't take a genius to know that Rhamondre Stevenson is an absolute must-play in Harris' absence. Dating back to last week, Harris appeared in just six snaps before hurting his hamstring. The veteran runner didn't return to the game and made way for Stevenson to secure a 90% snap share, 73.5% rushing share, and a 63.6% route participation metric. Across the board, Stevenson has legitimate RB1 potential, and he proved that with 19.5 fantasy points and an RB14 finish.

Of course, the Patriots are going to be better equipped this week with rookie Pierre Strong and practice squad call-up Kevin Harris joining the backfield, though neither player is likely to steal a ton of work away from Stevenson. He's a must-start player this week and should handle the majority of the available work in the backfield, though it is fair to expect Strong and maybe even Harris to mix in every few drives.

Miami Dolphins RB Raheem Mostert

Game status: Questionable

Injury: Knee

Mostert was listed as questionable by the Dolphins but expects to play. Over the past few weeks, the Dolphins have made a major transition in their backfield:

Originally, Miami looked as if they intended to deploy some sort of a 50/50 type of split in their backfield with Edmonds mostly leading the way. Over the past two weeks, Edmonds has taken a major backseat to Mostert, who has clearly separated himself from the pact. Mostert is playing the most snaps, handling the majority of the work, and is even running the most routes out of the backfield:

This wasn't exactly just a one-week affair, either. In Week 4, Mostert got the majority of opportunities, too:

Snaps: Mostert (46), Edmonds (18)

Rushing attempts: Mostert (15), Edmonds (5)

Routes run: Mostert (26), Edmonds (9)

As of now, Mostert is expected to play. There could be some concern that his knee issue forces the Dolphins to scale back his workload a little bit and in turn gives Edmonds a few more opportunities, though we can't rely solely on that. Mostert is a strong play while Edmonds is a bench stash at best right now.

New Orleans Saints WR Chris Olave

Game status: Questionable

Injury: Concussion

The Saints have a major issue as it pertains to their receiver room. Olave is currently being listed as questionable heading into Week 6, while Jarvis Landry, Michael Thomas, and Deonte Harty have already been ruled out. If Olave is able to suit up in this contest, he'll have all the targets needed to put together a strong performance once again.

As you can see, Olave has been a fairly steady player across the board. His numbers were understandably down this past week, though didn't get to play the full contest because of a concussion. If he's available to play, Olave is a near certainty to reach his consistent 25.0% in target share and should once again reach double-digit fantasy points in full-point PPR leagues. If entirely healthy and ready for a full workload, Olave legitimately has WR2 potential and could creep even higher, even against a tough Cincinnati Bengals defense that's allowed the fifth-fewest points to opposing receivers.

Los Angeles Chargers WR Keenan Allen

Game status: Doubtful

Injury: Hamstring

Once again, Allen considers himself doubtful to suit up in Week 6. The star slot receiver has played in just one game this season and seems certain to be sidelined again this weekend. We've got a strong pulse on what the Chargers are offensively at this point without Allen. Mike Williams is the team's No. 1 receiver and a must-start in fantasy leagues, second-year player Josh Palmer is the No. 2 receiver though he's lacked the production to match, and DeAndre Carter rounds out the trio at the position as the guy who lines up in the slot most often.

Unfortunately for those looking at replacement receivers, Los Angeles likely isn't the place. Carter has had one double-digit point finish since Week 1 and is trending in the wrong direction recently, and Palmer is nearly identical with just one double-digit point finish back in Week 3.

Allen's absence has been a major positive for Austin Ekeler's fantasy output, though, as the star runner has emerged as fantasy football's RB1 over the past five weeks with 113.7 fantasy points.

Cincinnati Bengals WR Tee Higgins

Game status: Questionable

Injury: Ankle

An ankle injury has bothered Higgins for some weeks now and limited the stud to just 10 snaps in Week 5. Higgins re-aggravated the injury and is clearly not fit to perform up to his standards, though it remains to be seen whether he'll suit up or not. Leaving Higgins on the bench for this week seems like a wise play, even if he's active. The Bengals would be wise to allow him to rest for a week and finally get over the hump.

Going back to last week, no player saw a bigger opportunity boost than wide receiver Mike Thomas. The veteran had just two targets, though he ran 28 routes on 35 dropbacks and played 45 out of 63 snaps. There is no reason to play Thomas this week, though Ja'Marr Chase, Tyler Boyd, and tight end Hayden Hurst should see an uptick in opportunities if Higgins can't go. Hurst is also currently listed as questionable, but has been the past few weeks and hasn't appeared limited to any degree.

New England Patriots TE Jonnu Smith

Game status: Questionable

Injury: Ankle

Smith — like Harris — is being listed as questionable, though he may be closer to doubtful. There isn't a ton of value in the Patriots' offense right now outside of the backfield or receiver Jakobi Meyers, but Hunter Henry could present an interesting opportunity as a streamable tight end. As we know, the position is terrible. Last week, Smith was ruled out with the same ankle injury and Henry was able to benefit from his absence:

Week 4

Snap share: 84.5%

Route participation: 56.0%

Week 5

Snap share: 98.3%

Route participation: 81.8%

Henry isn't going to light the world on fire, but he could produce a start-worthy performance in a pinch.